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Home » Blog » What is the pore size range available for PTFE syringe filters?

Syringe filters play an essential role in laboratory applications, helping filter samples to remove particulate matter and maintain the purity of desired solutions. Of the various types of syringe filters available, PTFE (polytetrafluoroethylene) filters have become particularly popular due to their superior chemical resistance, hydrophobicity, and compatibility with an array of solvents – making them widely utilized across analytical chemistry, pharmaceutical research, biotechnology research, and other scientific fields.


1. Understanding PTFE Syringe Filters

PTFE syringe filters feature porous membranes made of synthetic fluoropolymer material called PTFE, which has the unique property of being chemically inert, making these filters suitable for applications involving challenging or aggressive samples. PTFE’s chemical inertness means it is capable of withstanding solvents, acids, and bases which render these filtration solutions suitable for applications involving such contaminants as acids or bases that attack other materials.


2. Axiva Syringe Filter: A Reliable Option

Axiva Syringe Filters are Dependablelosung Axiva’s syringe filters are well-renowned for their top-quality performance and consistent results, featuring a diverse selection of PTFE syringe filters with various pore sizes to meet specific laboratory needs. Their aim is to ensure efficient filtration while maintaining low extractable levels for reduced sample loss and extractable levels.


3. Understanding Pore Size Options

A syringe filter’s pore size is a crucial criterion that determines its filtration efficiency and particle retention capability, so choosing an ideal filter for each application requires exploring all available pore sizes PTFE filters offer. Here we highlight some commonly-available sizes in order to facilitate decision-making:


A: 22mm Filters for Coarse Filtration

A 22mm filter is typically categorized as a coarse filtration option, designed to remove larger particles and debris from samples in an initial effort at clarification. This pore size can help eliminate unwanted particulate matter without a significant adverse effect on analytes of interest.


B: 1.45mm PTFE Syringe Filters Are Versatile Filtration Solutions

The 0.45mm pore size of PTFE syringe filters has become one of the most preferred selections due to its efficient removal of microorganisms, particulates, and colloids for optimal filtration efficiency. Among various uses for 0.45mm filters include sterile filtration, sample preparation, and clarification of solutions.


C: Corning 431219 Syringe Filters Provide Reliable Filtration

Corning 431219 is a reputable provider of laboratory supplies, such as PTFE syringe filters. Their filters come with different pore sizes to meet researchers’ flexible filtration needs while remaining reliable; with these filters from Corning 431219, users can expect superior filtration performance and consistent retention of particles.


D: Puradisc: Precision Filtration Solution

Puradisc offers an extensive selection of PTFE syringe filters designed to meet diverse laboratory requirements. Their filters are known for their precise and efficient filtration capabilities – perfect for clarifying aqueous or solvent-based samples or extracting submicron particles efficiently and reproducibly.


4. Additional Options and Considerations


Beyond the brands and pore sizes mentioned earlier, other notable PTFE syringe filter options available on the market include Millex GP filters, Millex GS filters, Minisart NML, MDI syringe filters, and Sterifilt syringe filters, which offer different pore sizes to meet different filtration needs. These filters have proven optimal performance as they work effectively with various solvents and sample types enhancing PTFE’s versatility across various laboratory settings.


5. Selecting the Appropriate Pore Size

Selecting an ideal pore size for your filtration application is of critical importance for accurate and reliable results. It depends on several factors including sample characteristics, particle retention requirements, and desired filter levels.


For applications where coarse filtration is sufficient, such as the removal of large particles or debris, 22mm PTFE syringe filters provide an ideal initial clarification step that ensures cleaner samples for subsequent analysis.


If the objective is to remove microorganisms, colloids, or fine particles, a 0.45mm PTFE syringe filter is often recommended as it offers effective filtration while still permitting most analytes through. As such, it can serve for sterilization, sample preparation, and clarification purposes.



PTFE syringe filters are widely utilized in laboratories due to their chemical resistance and compatibility with numerous solvents. Thanks to various pore size options – 22mm and 0.45mm are popular examples – researchers can tailor the filtration process according to specific needs.


Leading manufacturers such as Axiva, Corning 431219, Puradisc Millex Minisart MDI, and Sterifilt offer reliable PTFE syringe filters of the highest quality to help scientists achieve precise and accurate results in various applications from routine sample preparation to advanced analytical procedures. By choosing an appropriate pore size and using these advanced filters effectively scientists can achieve precise and accurate results from routine sample preparation procedures to more intricate analytical procedures.


Be sure to choose a filter pore size that best meets your requirements based on the nature of the sample and desired level of filtration. By using PTFE syringe filters, you can enhance the purity and integrity of samples collected for research, ultimately furthering scientific discoveries.

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