English 中文
Your Position :
Home » Products » HPLC Syringe Filters » PTFE Syringe Filters: Using Guides, Advantages, Price, Pore Size, Working Principle, Applications, Compatibility, Comparison, Troubleshooting Guide, Performance Metrics, Care and Maintenance, FAQs
The Main Parameter

Introduction of the PTFE Syringe Filter


The PTFE syringe filter is a crucial tool in laboratories, offering precise filtration capabilities. It comprises a hydrophilic PTFE membrane within a durable polypropylene housing. With exceptional chemical resistance, these filters are compatible with a wide range of solvents, acids, and bases. PTFE syringe filters are constructed using advanced manufacturing techniques, ensuring consistent quality and performance. They are available in various configurations, including different pore sizes, to cater to specific laboratory needs. With their hydrophilicity and efficient flow rates, PTFE syringe filters enable efficient sample preparation and reliable filtration results. Overall, PTFE syringe filters are indispensable in diverse laboratory applications, providing researchers with a versatile and reliable filtration solution.


Working Principle of the PTFE Syringe Filter


The PTFE syringe filter operates on a unique working principle. Its hydrophobic polytetrafluoroethylene (PTFE) membrane repels water and other polar solvents. As a liquid sample is pushed through the filter, the membrane acts as a barrier, allowing only the solvent to pass through while capturing particles, impurities, and microorganisms. The hydrophobic nature of PTFE enables the liquid to flow quickly through the membrane, leaving behind unwanted substances. The membrane contains microscopic pores that determine the filtration precision, with sizes ranging from 0.45 µm to smaller options like 0.2 µm or 0.22 µm. Applied pressure or vacuum facilitates liquid flow, ensuring effective particle capture without clogging. PTFE syringe filters are primarily designed for liquid filtration and may not be suitable for air or gas sampling. Understanding this working principle helps in selecting the appropriate filter and optimizing the filtration process.


8 Highlights and Advantages of the PTFE Syringe Filter


The PTFE syringe filter offers numerous highlights and advantages that make it a preferred choice for many laboratory applications. Let’s explore some of its key features:


1. Chemical Resistance

One of the primary advantages of PTFE syringe filters is their exceptional chemical resistance. They can withstand exposure to a wide range of solvents, acids, and bases, ensuring compatibility with various sample types. This chemical resistance allows researchers to confidently filter samples without concerns of filter degradation or leaching of unwanted substances.


2. Hydrophobic Nature

PTFE is a hydrophobic material, meaning it repels water and other polar solvents. This property is advantageous in applications involving non-aqueous solutions or samples with low surface tension. The hydrophobicity of the PTFE membrane prevents it from wetting out, ensuring efficient filtration and preventing liquid breakthrough.


3. Broad Compatibility

PTFE syringe filters exhibit compatibility with a wide range of solvents, including aggressive organic solvents and corrosive chemicals. This versatility allows researchers to use the filters across various laboratory processes, such as clarifying samples, removing particulates, and sterilizing solutions.


4. High Filtration Efficiency

PTFE syringe filters offer excellent filtration efficiency, effectively removing particles, impurities, and microorganisms from samples. The microscopic pores of the membrane ensure precise filtration, with pore sizes ranging from 0.45 µm to smaller sizes like 0.2 µm or 0.22 µm. This level of filtration accuracy is crucial for applications that require reliable and consistent results.


5. Low Extractables 

PTFE syringe filters are known for their low extractable levels, meaning they release minimal contaminants into the filtered sample. This characteristic is especially important in sensitive applications, such as pharmaceutical or biotechnological research, where the purity of the final product is critical.


6. Ease of Use

PTFE syringe filters are user-friendly and easy to operate. They are designed for compatibility with standard syringes, allowing for convenient and efficient filtration directly into sample vials or containers. The filters typically feature a luer lock or luer slip connection, ensuring a secure and leak-free setup.


7. Versatility in Applications

PTFE syringe filters find application across various industries, including pharmaceutical, environmental, food and beverage, and research laboratories. They are commonly used for sample preparation, clarifying solutions, removing particulates, and ensuring the purity of samples before analysis or downstream processes.


8. Cost-Effective Solution

PTFE syringe filters offer a cost-effective solution for filtration needs. They are available in different sizes and quantities, allowing researchers to choose the most suitable option based on their specific requirements. The durability and longevity of PTFE filters further contribute to their cost-effectiveness.


These highlights and advantages collectively make PTFE syringe filters a reliable and versatile tool in the laboratory. Their chemical resistance, hydrophobic nature, high filtration efficiency, and compatibility with a wide range of solvents position them as a preferred choice for critical filtration applications.


Applications of the PTFE Syringe Filter


The applications of PTFE syringe filters are diverse and span various industries, where precise and reliable filtration is crucial for sample preparation and analysis. The unique properties of PTFE syringe filters make them well-suited for a wide range of applications. Here are some notable applications where PTFE syringe filters are commonly employed:


Pharmaceutical Analysis: PTFE syringe filters play a vital role in pharmaceutical laboratories, where they are used for the filtration of drug formulations, quality control testing, and sample preparation for analytical techniques such as high-performance liquid chromatography (HPLC) and gas chromatography (GC). These filters ensure the removal of particulates, microorganisms, and unwanted impurities from pharmaceutical samples, enabling accurate and reliable analysis.


Environmental Monitoring: PTFE syringe filters are extensively utilized in environmental analysis and monitoring. They help in the filtration of water samples for the detection and quantification of pollutants, including heavy metals, organic compounds, and microplastics. PTFE syringe filters are also employed in air and gas sampling for monitoring airborne particulates and pollutants in environmental studies.


Food and Beverage Analysis: In the food and beverage industry, PTFE syringe filters find applications in quality control and safety testing. They are used to filter samples for the analysis of contaminants, such as pesticides, mycotoxins, and microbial contaminants. PTFE syringe filters enable the removal of unwanted particles, ensuring accurate and reliable analysis of food and beverage samples.


Research and Development: PTFE syringe filters are extensively utilized in research and development laboratories across various scientific disciplines. They are employed for the filtration and clarification of samples, including cell culture media, buffers, reagents, and protein solutions. PTFE syringe filters help in removing particulates, bacteria, and other impurities, ensuring the purity and integrity of samples in research studies.


Biotechnology and Life Sciences: PTFE syringe filters are crucial in biotechnology and life sciences applications. They are commonly used for the filtration of biological samples, such as cell cultures, cell lysates, and protein solutions. PTFE syringe filters aid in the removal of cellular debris, microorganisms, and aggregates, ensuring the purity and sterility of the samples for downstream applications, including molecular biology, genomics, and proteomics.


Industrial Filtration: PTFE syringe filters find applications in industrial processes where precise filtration is required. They are used for the filtration of solvents, oils, and other industrial fluids to remove contaminants and ensure the quality of the final product. PTFE syringe filters are also employed in the electronics industry for the filtration of electronic-grade chemicals and solutions, ensuring the removal of particles that could interfere with manufacturing processes.


Laboratory Filtration: PTFE syringe filters serve as a versatile tool in various laboratory filtration applications. They are used for general filtration and clarification of samples, removal of particles, microorganisms, and aggregates, and sterilization of liquids. PTFE syringe filters are compatible with a wide range of solvents and are suitable for filtration in both aqueous and non-aqueous solutions.


The wide range of applications demonstrates the versatility and reliability of PTFE syringe filters in different industries and laboratory settings. By providing effective filtration and ensuring the purity of samples, PTFE syringe filters contribute to accurate and reliable analysis, enabling advancements in scientific research, quality control, and environmental monitoring.


Hydrophilic PTFE Syringe Filter VS Hydrophobic PTFE Syringe Filter


Attribute Hydrophilic PTFE Syringe Filter Hydrophobic PTFE Syringe Filter
Membrane Property Treated to be hydrophilic, has an affinity for water Inherently hydrophobic, repels water and polar solvents
Filtration Compatibility Suitable for aqueous and non-aqueous solutions Primarily used for non-aqueous solutions or samples with low surface tension
Suitable Applications Pharmaceutical or biological sample preparation, water-based environmental analysis Organic solvents, oils, non-aqueous solutions, aggressive chemicals
Sample Adsorption/Binding Minimizes the potential for sample adsorption or binding, ensuring minimal loss of analytes Prevents the filter from wetting out, allowing for faster filtration and reduced sample breakthrough
Flow Rates May have slightly lower flow rates due to affinity for water, excellent chemical resistance Generally higher flow rates due to hydrophobic nature, may not provide optimal filtration for aqueous solutions
Solvent Compatibility Compatible with aqueous solutions, alcohols, and other polar solvents Compatible with organic solvents, oils, and non-polar solutions
Applications HPLC sample preparation, protein and peptide analysis, water-based environmental analysis Filtration of organic solvents, oils, aggressive chemicals, non-polar solutions


Hydrophilic PTFE syringe filters are treated to have a hydrophilic membrane, allowing for the filtration of both aqueous and non-aqueous solutions. They are commonly used in applications where water-based solutions need to be filtered, such as pharmaceutical or biological sample preparation and water-based environmental analysis. The hydrophilic property of the membrane reduces the potential for sample adsorption or binding, ensuring minimal loss of analytes. Although they may have slightly lower flow rates, hydrophilic PTFE syringe filters offer excellent chemical resistance.


On the other hand, hydrophobic PTFE syringe filters have an inherently hydrophobic membrane that repels water and other polar solvents. They are primarily used for filtering non-aqueous solutions or samples with low surface tension. Hydrophobic filters are commonly employed in applications involving organic solvents, oils, aggressive chemicals, and non-polar solutions. Their hydrophobic nature prevents the filter from wetting out, allowing for faster filtration and reducing the potential for sample breakthrough. Hydrophobic PTFE syringe filters generally have higher flow rates but may not provide optimal filtration for aqueous solutions.


Understanding the differences between hydrophilic and hydrophobic PTFE syringe filters enables researchers to select the most suitable filter based on their specific sample characteristics and filtration requirements.


Product Range of the PTFE Syringe Filter


The product range of PTFE syringe filters is extensive, offering a multitude of options to meet various filtration requirements in laboratory and research settings. These filters are designed with different specifications, including pore size, membrane diameter, and filter configuration, providing versatility and customization for different applications.


Pore size is a critical consideration when selecting a PTFE syringe filter. Common pore sizes range from 0.45 µm to smaller sizes like 0.22 µm or 0.2 µm. Filters with smaller pore sizes offer higher filtration precision by effectively capturing smaller particles and microorganisms, making them ideal for applications requiring finer filtration. On the other hand, filters with larger pore sizes like 0.45 µm provide a broader filtration range and are commonly used for general filtration purposes where a high flow rate is desired.


The membrane diameter of PTFE syringe filters also varies, typically ranging from 13 mm to larger diameters like 25 mm or 33 mm. The choice of membrane diameter depends on the volume of the sample to be filtered. Smaller diameter filters are suitable for filtering smaller sample volumes or when space is limited, while larger diameter filters accommodate higher sample volumes and provide faster filtration rates.


In addition to pore size and membrane diameter, PTFE syringe filters come in various filter configurations to cater to different needs. Some common filter configurations include non-sterile, sterile, syringeless, pre-sterilized, and pre-wetted filters. Non-sterile filters are suitable for noncritical applications where sterility is not a requirement. Sterile filters, on the other hand, are essential for applications that demand aseptic conditions, such as cell culture or pharmaceutical preparations. Syringeless filters eliminate the need for a separate syringe, simplifying the filtration process and reducing the risk of contamination. Pre-sterilized and pre-wetted filters are convenient options that save time and ensure ready-to-use filters for immediate filtration needs.


By offering a diverse range of pore sizes, membrane diameters, and filter configurations, the product range of PTFE syringe filters allows researchers and laboratory professionals to select the most appropriate filter for their specific applications. This ensures efficient and reliable filtration, leading to accurate and precise results in various scientific and analytical processes.


6 Performance Metrics of the PTFE Syringe Filter


When it comes to filtration in laboratory settings, the performance of a syringe filter is of utmost importance. PTFE (polytetrafluoroethylene) syringe filters are widely used due to their exceptional chemical resistance, high-temperature tolerance, and low extractable levels. Understanding the performance metrics of PTFE syringe filters can help researchers make informed decisions and achieve accurate and reliable results.


Filtration Efficiency: The primary purpose of a syringe filter is to remove impurities and particulate matter from a sample. The filtration efficiency of a PTFE syringe filter refers to its ability to effectively capture contaminants of a specific size range. PTFE membranes are known for their excellent particle retention capabilities, ensuring that even microscopic particles are retained, while allowing the desired filtrate to pass through.


Flow Rate: The flow rate of a syringe filter is the speed at which the filtrate passes through the membrane. It is an important metric to consider, as it affects the efficiency and convenience of the filtration process. PTFE syringe filters are available in various pore sizes, allowing researchers to select the appropriate filter based on their specific application requirements. Filters with larger pore sizes generally offer higher flow rates, enabling faster filtration.


Chemical Compatibility: PTFE syringe filters exhibit exceptional chemical resistance, making them compatible with a wide range of solvents, acids, and bases. This characteristic is crucial when filtering samples that contain organic solvents or aggressive chemicals. The chemically inert nature of PTFE ensures that the filter material does not react with the sample, preventing any interference or contamination.


Low Extractable Levels: Extractable levels refer to the amount of substances that can be released from the filter material and potentially contaminate the filtrate. PTFE syringe filters are known for their low extractable levels, minimizing the risk of introducing unwanted compounds into the sample. This is particularly important in sensitive analytical techniques where sample purity is paramount.


Sample Compatibility: PTFE syringe filters are suitable for a wide range of sample types, including aqueous solutions, organic solvents, and aggressive chemicals. Their compatibility with different sample matrices ensures versatility and applicability across various laboratory applications.


Physical Integrity: The physical integrity of a syringe filter is crucial for maintaining its performance. PTFE syringe filters are designed to withstand high pressures during filtration without membrane rupture or leakage. This durability ensures the filter’s longevity and reliability, allowing researchers to confidently perform their experiments without concerns about filter failure.


By considering these performance metrics, researchers can select the appropriate PTFE syringe filter for their specific application. Whether it’s achieving high filtration efficiency, fast flow rates, chemical compatibility, low extractable levels, sample versatility, or physical integrity, PTFE syringe filters offer reliable performance and contribute to accurate and precise laboratory analyses.


Compatibility with Automated Systems


As laboratories embrace automated systems to increase efficiency and productivity, compatibility of PTFE (polytetrafluoroethylene) syringe filters with these automated systems becomes ever more crucial. PTFE filters boast many advantages such as chemical resistance, low extractable levels, and efficient filtration; in this article, we will examine their integration seamlessly.


Design and Compatibility: PTFE syringe filters come in various designs to accommodate automated systems. Common sizes for automated filtration setups such as 13mm or 25mm filters should ensure compatibility. When purchasing filters specifically made for automated use it is important to verify they will meet these criteria.


Luer Lock Connection: Automated systems often utilize luer lock connections for secure, leak-free connections. PTFE syringe filters equipped with luer lock fittings are easily compatible with these automated systems and ensure a tight seal during filtration, helping ensure its accuracy and reliability. Luer lock fittings make for simple use while protecting against potential leakage that could compromise the accuracy or reliability of filtration processes.


Membrane Integrity and Robustness: Automated filtration processes involve high pressures and repeated use. Therefore, selecting PTFE syringe filters that can withstand these rigorous demands of automated systems is of utmost importance. PTFE membranes have excellent chemical resistance as well as physical durability characteristics which makes them suitable for repeated usage to preserve membrane integrity over extended periods.


Filtration Efficiency and Flow Rates: Automated systems rely heavily on efficiency, making filtration speed a key consideration. PTFE syringe filters offer exceptional flow rates, making PTFE syringe filters ideal for quick and effective filtration even when integrated into automated systems. When selecting filters with automated setups it is critical that they match up perfectly in terms of pore size specifications as well as flow rates that meet these criteria.


Validation and Performance: Before incorporating PTFE syringe filters into automated systems, it is highly advisable to conduct validation studies to verify their performance standards are being met consistently. This process involves testing their compatibility, efficiency, and reliability within their automated environment in order to assess their suitability for specific applications.


Workflow Optimization: Compatibility between PTFE syringe filters and automated systems contributes to workflow optimization. By seamlessly integrating into automated sample preparation, purification, or analysis processes – thus eliminating manual handling and risk of errors – researchers can maximize productivity, save time and improve laboratory efficiency by streamlining their filtration process.


PTFE syringe filters can easily be integrated into automated systems, providing compatibility, reliability, and efficient filtration. With their standard designs, luer lock connections, robust membrane construction, and high flow rates PTFE syringe filters offer a seamless filtration experience within automated setups. By considering compatibility factors and conducting validation studies laboratories can maximize the performance of their automated systems by taking advantage of these filters.


6 Notable Advantages of PTFE Syringe Filter Comparison with Other Types


Laboratory filtration offers researchers numerous filter types to meet the varied needs of researchers, with PTFE (polytetrafluoroethylene) syringe filters being one such example. When considering these filters for particular applications, it is vital that researchers gain an understanding of how they compare with other filter types in terms of performance, compatibility, and suitability for particular tasks – in this article, we compare PTFE syringe filters against commonly used filter types to provide insights into their strengths and limitations.


Chemical Resistance: PTFE filters exhibit exceptional chemical resistance, making them compatible with a wide range of solvents, acids, and bases. They can withstand aggressive organic solvents and maintain their integrity during filtration.


Low Extractable Levels: PTFE filters have low extractable levels, meaning they release minimal contaminants into the filtrate. This property ensures sample purity and prevents interference in downstream analysis.


Temperature Tolerance: PTFE filters can withstand high temperatures without degradation, making them suitable for applications that involve elevated temperatures or sterilization processes.


Versatile Compatibility: PTFE filters are compatible with both aqueous and organic solvents, offering versatility in various laboratory applications. They can be used for filtration across a wide range of sample types and matrices.


Efficient Filtration: PTFE filters provide excellent filtration efficiency, effectively retaining particulate matter and microorganisms while allowing the desired filtrate to pass through. They offer reliable particle retention, ensuring accurate analysis and reliable results.


Broad Range of Pore Sizes: PTFE syringe filters are available in a wide range of pore sizes, allowing researchers to select the appropriate filter based on their specific filtration needs. This flexibility enables fine or coarse filtration, depending on the application requirements.


Filter Type Filtration Efficiency Compatibility Chemical Resistance Protein Binding Flow Rate
PTFE Syringe Filters Excellent Wide range of solvents, acids, bases Highly resistant Low Moderate to Fast
Cellulose Acetate (CA) Good Aqueous solutions, limited for organics Moderate Relatively high Moderate
Nylon Filters High Aqueous solutions, organic solvents Good Moderate Fast (with larger pores)
PVDF Filters High Organic solvents, acids, bases Excellent Low Moderate to Fast
Glass Fiber Filters High Aqueous solutions, limited for organics Good Relatively high Moderate

Cellulose Acetate (CA) Filters


Filtration Efficiency: CA filters typically possess impressive filtration efficiency for particulate removal, though their chemical resistance may be limited.


Compatibility: CA filters can handle most aqueous solutions, including biological samples. They may not, however, be suitable for organic solvents or aggressive chemicals.


Protein Binding Capacity: CA filters have a relatively higher protein binding capacity compared to PTFE filters, which may be an important consideration in protein analysis applications.


Flow Rates: Depending on their pore size, CA filters typically offer moderate flow rates.


Nylon Filters 


Filtration Efficiency: Nylon filters are known for their superior filtration efficiency and particle retention capacities, making them highly sought-after filters for particle retention applications.


Compatibility: Nylon filters can be used with both aqueous solutions and organic solvents, making them versatile in their application options.


Chemical Resistance: While nylon filters offer good chemical resistance, they may not be appropriate for solutions containing strong acidic or alkaline constituents. 


Protein Binding Capacity: Nylon filters have a moderate protein binding capacity which should be considered when used for protein analysis applications.


Flow Rate: Nylon filters typically offer faster flow rates, particularly those with larger pore sizes.


PVDF (Polyvinylidene Fluoride) Filters


Filtration Efficiency: PVDF filters feature excellent filtration efficiency and particle retention rates, making them suitable for many different applications.


Compatibility: These versatile filters exhibit broad compatibility with organic solvents, acids, bases, and aqueous solutions making them suitable for use across an array of environments.


Chemical Resistance: PVDF filters boast excellent chemical resistance even against aggressive solvents and chemicals, such as those present in aggressive solvents and chemicals.


Protein Binding Capacity: PVDF filters feature low protein binding capacity making them perfect for protein analysis as well as other sensitive applications.


Flow Rate: PVDF filters typically offer moderate to fast flow rates depending on their pore size. 


Glass Fiber Filters


Filtration Efficiency: These glass fiber filters boast excellent filtration efficiency that can retain both particulate matter and microorganisms.


Compatibility: Glass fiber filters are generally compatible with aqueous solutions; however, organic solvents or certain aggressive chemicals may not be appropriate.


Chemical Resistance: Glass fiber filters boast excellent chemical resistance for most common laboratory uses.


Protein Binding Capacity: Glass fiber filters boast an exceptional protein binding capacity that should be considered in protein analysis applications. Flow Rates: Glass fiber filters typically offer moderate flow rates depending on their thickness and density, making them suitable for applications involving protein analysis.


Quality Assurance of the PTFE Syringe Filter


The quality and reliability of PTFE (polytetrafluoroethylene) syringe filters are essential to producing accurate laboratory results, with manufacturers employing stringent quality assurance measures throughout production to maintain the performance and integrity of these filters. Here we discuss key aspects of quality assurance for PTFE syringe filters.


Raw Material Selection: The quality assurance process begins with selecting high-grade raw materials. Reputable manufacturers select their PTFE membranes and other components from reliable suppliers to meet stringent quality standards, and these undergo thorough testing and inspection processes to guarantee they are defect-free and free from contamination.


Manufacturing Processes: Quality assurance extends to the processes employed to assemble PTFE syringe filters. These processes adhere to established protocols and industry best practices. Quality control checks are conducted throughout the assembly to monitor and verify their integrity.


Performance Evaluation: PTFE syringe filters undergo stringent performance testing to verify their filtration efficiency, flow rates, and retention capabilities meet set standards. Testing includes subjecting them to various particle sizes and concentrations to measure how well they meet or surpass performance standards in real-world conditions. This helps ensure the filters always live up to or surpass them.


Chemical Compatibility Testing: PTFE syringe filters undergo compatibility testing against an extensive selection of solvents, acids, bases, and other chemicals to ensure they retain their chemical resistance and integrity when exposed to different substances. Compatibility testing provides confidence in their ability to withstand aggressive chemicals while upholding sample purity.


Quality Control Inspections: At each stage in the production process, quality control inspections are conducted to detect any defects, inconsistencies, or deviations from specifications. These may involve visual checks, dimensional measurements, or other quality tests conducted to ensure each filter satisfies standards set by its respective specifications.


Sterilization Validation: Filters intended for sterile applications require sterilization validation as part of their quality assurance process. Sterilization methods like gamma irradiation or ethylene oxide sterilization must be properly verified to ensure they sterilize filters without degrading performance or producing any potentially harmful residuals.


Traceability and Documentation: For robust quality assurance systems to operate effectively, each batch of PTFE syringe filters must be properly traced and documented from raw materials through to finished filters allowing full product traceability from raw materials through production and on to consumer use allowing quick identification and resolution of any potential issues that may arise.


Manufacturers of PTFE syringe filters employ these quality assurance measures to ensure each filter meets the required performance specifications, giving researchers confidence in its reliability and performance, and helping them produce accurate and repeatable laboratory work results.


Compatibility Guides


To assist researchers in selecting the appropriate PTFE (polytetrafluoroethylene) syringe filters for their specific applications, manufacturers often provide compatibility guides. These guides offer valuable information about the chemical resistance and compatibility of PTFE filters with various solvents, acids, bases, and other chemicals. In this article, we will explore the importance of compatibility guides and how they aid researchers in making informed decisions.


Type Chemical Compatibility with PTFE Syringe Filters
Solvents Alcohols Compatible
Acetone Compatible
Benzene Not Recommended
Chloroform Compatible
Dichloromethane Compatible
Diethyl ether Compatible
Dimethyl sulfoxide (DMSO) Compatible
Ethanol Compatible
Ethyl acetate Compatible
Hexane Compatible
Isopropanol Compatible
Methanol Compatible
Tetrahydrofuran (THF) Compatible
Acids Hydrochloric acid Compatible
Sulfuric acid Compatible
Nitric acid Compatible
Phosphoric acid Compatible
Acetic acid Compatible
Bases Sodium hydroxide Compatible
Potassium hydroxide Compatible
Ammonium hydroxide Compatible
Other Chemicals Water Compatible
Dimethylformamide (DMF) Compatible
Acetonitrile Compatible
Sodium chloride (NaCl) solution Compatible
Sodium carbonate (Na2CO3) solution Compatible
Sodium phosphate buffer solution Compatible


By consulting compatibility guides from reliable manufacturers, researchers can make informed choices when it comes to selecting PTFE syringe filters compatible with their specific solvents, acids, bases, and chemicals. These guides help ensure the integrity of the filtration process, preserve sample purity, and reduce risks such as filter failure or contamination.


7 Care and Maintenance Practices of the PTFE Syringe Filter


Proper care and maintenance of PTFE (polytetrafluoroethylene) syringe filters are crucial to their optimal performance and longevity, enabling researchers to achieve reliable and accurate filtration results from these filters. Here are some key care and maintenance practices for PTFE syringe filters:




Wash hands regularly or wear disposable gloves when handling PTFE syringe filters to minimize contamination transference. Avoid touching any part of a filter that will come into contact with samples, as doing so may introduce fingerprints or debris that interfere with its filtration process.




Prior to filtering, it is recommended to pre-wet the PTFE syringe filter with an appropriate solvent or sample matrix. Prewetting enhances filter membrane wettability while helping eliminate air bubbles, leading to improved filtration efficiency. Filtration Setup:  Filtration setup involves pre-wetting of the filter membrane by pre-wetting with solvent or sample matrix before filtration begins.


Filtration Setup


Make sure that the syringe, filter, and any associated fittings are free from debris or residues before attaching the filter with adapters or luer lock connections – this ensures leak-free connections during filtration.




Confirm the compatibility between PTFE syringe filters and the solvent, acid, base, or sample matrix being filtered. Referring to your manufacturer’s compatibility guide or conducting compatibility testing will ensure the filter’s resistance against specific substances involved.


Flow Rate


Maintain an appropriate flow rate during filtration to avoid excessive pressure or potential filter membrane damage. Make necessary changes, such as using a larger syringe or filter with larger pores if necessary, in order to achieve your desired flow rate.


Single-Use Principle


PTFE syringe filters are generally designed for single-use applications and it is advised that new, sterile filters be used each time to avoid cross-contamination and ensure reliable results.




After filtering, dispose of your used syringe filter in accordance with laboratory safety protocols and thoroughly clean your filtration setup, including its components such as adapters or the syringe itself, to remove any contaminants or residue that could disrupt future filtration processes. 




Store PTFE syringe filters in a clean, dry environment to avoid exposure to moisture, dust, or contaminants. Label and organize filters appropriately so as to maintain traceability and avoid confusion during future use.


Researchers can optimize the performance and longevity of PTFE syringe filters with proper care and maintenance practices. Proper handling, prewetting, ensuring compatibility, maintaining appropriate flow rates, adhering to single-use principle and storage are all crucial for accurate filtration results.


5 Common Troubleshooting Guide of the PTFE Syringe Filter


Issues may arise during the use of PTFE (polytetrafluoroethylene) syringe filters that interfere with their filtration efficiency or lead to unexpected results, requiring researchers to address common problems encountered with such filters by following this troubleshooting guide. By following its steps, researchers can effectively address potential issues, guaranteeing optimal filter performance and reliable filtration results.


Low Flow Rate


When faced with low flow rates, first ensure the filter is clear of debris. If this is suspected, switch out for a different filter to see if its flow rate improves.


Furthermore, make sure that its pore size corresponds with that of your sample material; using larger pores could increase flow rates.


Make sure that the sample viscosity is not too high as this could impede its flow and necessitate further diluting of it. Dilution may be necessary. Verify that the syringe, needle, or any other components used in the filtration setup are not causing flow restrictions. Clean or replace any components which could be impeding the flow.


Leakage or Poor Seal


To prevent leakage or loss of sample, always use an adapter with a luer lock connection when connecting syringe filters to syringes using an appropriate seal, such as luer locks.


Check the condition of the filter housing; any visible cracks or damage should prompt replacement with a new filter. Inspect the integrity of the filter membrane to detect torn or damaged areas that might compromise filtration efficiency or lead to leakage issues.


Filtration Ineffectiveness


Check that the filter pore size matches your desired filtration needs; using one with smaller pores could improve efficiency for smaller particles.


Before using, pre-wet your filter with an appropriate solvent or sample matrix to enhance wetting properties and boost filtration efficiency.


Make sure your sample is prepared carefully, free from large particles or debris that could clog your filter. If necessary, filter it through a larger pore-size filter in order to eliminate potential contaminants.


Contaminant Breakthrough


Confirm that your filter’s pore size matches up with the particles you wish to retain, and consider switching out for one with smaller pores if necessary.


Checking compatibility between a filter and its solvent or sample matrix to avoid chemical reactions that could result in contamination breakthroughs.


If using multiple filters in series, inspect each to identify where a breakthrough is occurring and consider either changing your filtration setup or opting for different filter combinations.


Sample Loss


For optimal filtration flow, ensure the plunger of your syringe is pushed gently so as to maintain an orderly and steady filtration flow. Any excessive force could result in sample loss or splashing and should therefore be avoided at all costs.


Verify the connections between the syringe and filter to ensure a tight seal; any loose connections could result in sample leakage.


Avoid overfilling your syringe, which could result in sample spillage or loss. Fill it at an appropriate volume that allows for smooth filtration without overflow.


If troubleshooting steps don’t resolve the issue or additional concerns arise, it is advised to refer back to the manufacturer or their customer support for additional guidance and help. Their expertise can address specific problems related to PTFE syringe filters while leading researchers toward optimal filtration performance.


PTFE Syringe Filter Price


The price for PTFE syringe filters depends on several variables, including brand, pore size, diameter, quantity, and supplier. They tend to fall between the mid and high price points due to their superior chemical resistance, low extractable levels, and durability.


Brand: Established brands within the filtration industry often produce PTFE syringe filters with an excellent track record for quality and dependability, commanding slightly higher prices due to their brand value and investment in research and development.


Pore Size: PTFE syringe filters come with pores of various sizes, typically between 0.1 microns and 5 microns or greater. Filters with smaller pore sizes may cost more due to additional manufacturing processes needed to achieve finer filtration capabilities.


Diameter: The diameter of a syringe filter can also have a substantial impact on its price, with typical sizes such as 13mm, 25mm and 33mm often commanding higher prices due to increased filter material requirements.


Quantity: When purchasing PTFE syringe filters in bulk quantities, their unit cost may often decrease as suppliers may offer bulk discounts or tiered pricing tiers based on volume.


Supplier: When buying PTFE syringe filters, the supplier or distributor from which they’re purchased can have an effect on price. Different companies may have various pricing, structures, promotions, or packaging options which could alter overall costs significantly.


Prioritize value and performance over price when purchasing PTFE syringe filters. High-quality filters can deliver more consistent and reliable results, leading to cost savings by eliminating repeated experiments or retesting procedures.


To determine the cost of PTFE syringe filters, it is wise to contact suppliers or visit their websites and obtain up-to-date pricing information. Comparing prices across suppliers as well as taking into account factors like shipping costs, availability, and customer support will allow researchers to make more informed purchasing decisions that fit within both their budget and filtration needs.


7 FAQs of the PTFE Syringe Filter


Can PTFE syringe filters be reused?

PTFE syringe filters are typically designed for single-use applications and should never be reused. Reusing filters could result in clogging, reduced efficiency or contamination issues; to ensure reliable results it is important that every filtration process uses new, sterile filters.


How should PTFE Syringe filters be stored?

PTFE syringe filters should be stored in an environment free from moisture, dust, and contaminants in order to ensure their integrity is preserved until use. It is best practice to keep them in their original packaging or sealed container to preserve their integrity before being deployed for use.


Can PTFE Syringe filters be used with viscous samples?

PTFE syringe filters are typically suitable for filtering viscous samples; however, extremely high-viscosity samples may require extra precautions or pre-filtration steps in order to ensure efficient filtration. Dilution or larger-pore size filters may help increase the flow rate when filtering such highly viscous substances.


What is the maximum operating temperature of PTFE Syringe Filters?

PTFE syringe filters are typically designed to withstand high temperatures, making them suitable for applications involving elevated temperatures. Their maximum operating temperature varies by brand and model; generally speaking, however, it lies between 100degC to 150degC.


Can PTFE Syringe filters be used for sterile filtration?

Yes, PTFE syringe filters are available with pre-sterilization for applications requiring sterile filtration, such as microbiology, cell culture, or sample preparation. These pre-sterilized filters can be found widely used across industries including microbiology, cell culture, and sample preparation.


How long can PTFE syringe filters be stored before being used?

PTFE syringe filters typically come with an expiration date that has been specified by their manufacturer, for optimal performance it is important to adhere to any storage guidelines provided and use your filter within that window of time.


Are PTFE syringe filters suitable for filtering small volumes of liquid?

PTFE syringe filters are commonly used for filtering small volumes, as they come in sizes 13mm to 25mm in diameter. These filters make an ideal addition to applications requiring precise filtration of small sample volumes such as HPLC sample prep or limited sample volume research experiments.

Related products
PTFE Syringe Filters: Using Guides, Advantages, Price, Pore Size,  Working Principle, Applications, Compatibility, Comparison, Troubleshooting Guide, Performance Metrics, Care and Maintenance, FAQs
PTFE Syringe Filters: Using Guides, Advantages, Price, Pore Size, Working Principle, Applications, Compatibility, Comparison, Troubleshooting Guide, Performance Metrics, Care and Maintenance, FAQs

Discover the comprehensive guide to PTFE syringe filters: benefits, pricing, pore size, applications, and troubleshooting. Maximize filtration efficiency and learn about care and maintenance. FAQs included.

HPLC Syringe Filters
HPLC Syringe Filters

Material: Nylon; Hydrophilic PVDF; Hydrophilic PTFE; Hydrophobic PTFE; PES; MCE; Hydrophilic PP; Cellulose Acetate(CA)
Qty/Pack: 100pcs/pack
Application: Filter
Payment: T/T
MOQ: 1 pack

Please feel free to submit your inquiry information to us. We will contact with you as soon as possible.
Country :
Quick Consultation
Copyright 2021 Zhejiang Aijiren Technology, Inc. All Rights Reserved.